Cargando…

G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

Dephosphorylation of eukaryotic translation initiation factor 2a (eIF2a) restores protein synthesis at the waning of stress responses and requires a PP1 catalytic subunit and a regulatory subunit, PPP1R15A/GADD34 or PPP1R15B/CReP. Surprisingly, PPP1R15-PP1 binary complexes reconstituted in vitro lac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Ruming, Rato, Cláudia, Yan, Yahui, Crespillo-Casado, Ana, Clarke, Hanna J, Harding, Heather P, Marciniak, Stefan J, Read, Randy J, Ron, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394352/ https://www.ncbi.nlm.nih.gov/pubmed/25774600 http://dx.doi.org/10.7554/eLife.04871

Ejemplares similares

Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation
por: Chambers, Joseph E, et al.
Publicado: (2015)

A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α
por: Crespillo-Casado, Ana, et al.
Publicado: (2018)

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
por: Crespillo-Casado, Ana, et al.
Publicado: (2017)

AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation
por: Preissler, Steffen, et al.
Publicado: (2017)

Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker
por: Preissler, Steffen, et al.
Publicado: (2015)

AMPylation matches BiP activity to client protein load in the endoplasmic reticulum
por: Preissler, Steffen, et al.
Publicado: (2015)

Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
por: Preissler, Steffen, et al.
Publicado: (2020)

Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK
por: Marciniak, Stefan J., et al.
Publicado: (2006)

A general strategy to construct small molecule biosensors in eukaryotes
por: Feng, Justin, et al.
Publicado: (2015)

The autoregulation of a eukaryotic DNA transposon
por: Claeys Bouuaert, Corentin, et al.
Publicado: (2013)

Measuring Protein Binding to F-actin by Co-sedimentation
por: Heier, Jonathon A., et al.
Publicado: (2017)

Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments
por: Hansen, Scott D, et al.
Publicado: (2015)

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome
por: Costa, Alessandro, et al.
Publicado: (2014)

Prefabrication of a ribosomal protein subcomplex essential for eukaryotic ribosome formation
por: Peña, Cohue, et al.
Publicado: (2016)

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes
por: Nillegoda, Nadinath B, et al.
Publicado: (2017)

Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments
por: He, Didi, et al.
Publicado: (2016)

A novel predicted ADP-ribosyltransferase-like family conserved in eukaryotic evolution
por: Wyżewski, Zbigniew, et al.
Publicado: (2021)

Bacterial actin MreB forms antiparallel double filaments
por: van den Ent, Fusinita, et al.
Publicado: (2014)

Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation
por: Georgescu, Roxana E, et al.
Publicado: (2015)

An Oligonucleotide-based Tandem RNA Isolation Procedure to Recover Eukaryotic mRNA-Protein Complexes
por: Iadevaia, Valentina, et al.
Publicado: (2018)

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation
por: Smith, Benjamin A, et al.
Publicado: (2013)

Correction: Bacterial actin MreB forms antiparallel double filaments
por: van den Ent, Fusinita, et al.
Publicado: (2014)

Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase
por: Langston, Lance, et al.
Publicado: (2017)

Refining the reaction mechanism of O(2) towards its co-substrate in cofactor-free dioxygenases
por: Silva, Pedro J.
Publicado: (2016)

Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers
por: Williams, Byron C, et al.
Publicado: (2014)

Structure of a AAA+ unfoldase in the process of unfolding substrate
por: Ripstein, Zev A, et al.
Publicado: (2017)

Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex
por: Aitken, Colin Echeverría, et al.
Publicado: (2016)

Higher-order phosphatase–substrate contacts terminate the integrated stress response
por: Yan, Yahui, et al.
Publicado: (2021)

Cofilin-induced unidirectional cooperative conformational changes in actin filaments revealed by high-speed atomic force microscopy
por: Ngo, Kien Xuan, et al.
Publicado: (2015)

The structure of the core NuRD repression complex provides insights into its interaction with chromatin
por: Millard, Christopher J, et al.
Publicado: (2016)

Sigma's Non-specific Protease Activity Assay - Casein as a Substrate
por: Cupp-Enyard, Carrie
Publicado: (2008)

A general method for determining secondary active transporter substrate stoichiometry
por: Fitzgerald, Gabriel A, et al.
Publicado: (2017)

Evolution of substrate specificity in a retained enzyme driven by gene loss
por: Juárez-Vázquez, Ana Lilia, et al.
Publicado: (2017)

In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing
por: Osuna, Beatriz A, et al.
Publicado: (2017)

Structure and substrate ion binding in the sodium/proton antiporter PaNhaP
por: Wöhlert, David, et al.
Publicado: (2014)

Tissue-specific and substrate-specific mitochondrial bioenergetics in feline cardiac and skeletal muscles
por: CHRISTIANSEN, Liselotte Bruun, et al.
Publicado: (2015)

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
por: Culurgioni, Simone, et al.
Publicado: (2017)

Stable isotopes of Hawaiian spiders reflect substrate properties along a chronosequence
por: Kennedy, Susan R., et al.
Publicado: (2018)

Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation
por: Smith, F Donelson, et al.
Publicado: (2013)

Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1
por: Rashid, Fahad, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_mlhq8kj0hss0duvv81l48c9q6u