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Systems Pharmacology Approach Toward the Design of Inhaled Formulations of Rifampicin and Isoniazid for Treatment of Tuberculosis

Conventional oral therapies for the treatment of tuberculosis are limited by poor antibiotic distribution in granulomas, which contributes to lengthy treatment regimens and inadequate bacterial sterilization. Inhaled formulations are a promising strategy to increase antibiotic efficacy and reduce do...

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Detalles Bibliográficos
Autores principales: Cilfone, NA, Pienaar, E, Thurber, GM, Kirschner, DE, Linderman, JJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394619/
https://www.ncbi.nlm.nih.gov/pubmed/26225241
http://dx.doi.org/10.1002/psp4.22