Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB

The tripartite efflux pump assembly AcrAB-TolC is the major multidrug resistance transporter in E. coli. The inner membrane transporter AcrB is a homotrimer, energized by the proton movement down the transmembrane electrochemical gradient. The asymmetric crystal structures of AcrB with three monomer...

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Detalles Bibliográficos
Autores principales: Wang, Beibei, Weng, Jingwei, Wang, Wenning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394701/
https://www.ncbi.nlm.nih.gov/pubmed/25918513
http://dx.doi.org/10.3389/fmicb.2015.00302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394701/
https://www.ncbi.nlm.nih.gov/pubmed/25918513
http://dx.doi.org/10.3389/fmicb.2015.00302

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