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Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB
The tripartite efflux pump assembly AcrAB-TolC is the major multidrug resistance transporter in E. coli. The inner membrane transporter AcrB is a homotrimer, energized by the proton movement down the transmembrane electrochemical gradient. The asymmetric crystal structures of AcrB with three monomer...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394701/ https://www.ncbi.nlm.nih.gov/pubmed/25918513 http://dx.doi.org/10.3389/fmicb.2015.00302 |