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A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue

Only native polypeptides are released from the endoplasmic reticulum (ER) to be transported at the site of activity. Persistently misfolded proteins are retained and eventually selected for ER-associated degradation (ERAD). The paradox of a structure-based protein quality control is that functional...

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Detalles Bibliográficos
Autores principales: Merulla, Jessica, Soldà, Tatiana, Molinari, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395132/
https://www.ncbi.nlm.nih.gov/pubmed/25694454
http://dx.doi.org/10.1091/mbc.E14-12-1615