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A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue
Only native polypeptides are released from the endoplasmic reticulum (ER) to be transported at the site of activity. Persistently misfolded proteins are retained and eventually selected for ER-associated degradation (ERAD). The paradox of a structure-based protein quality control is that functional...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395132/ https://www.ncbi.nlm.nih.gov/pubmed/25694454 http://dx.doi.org/10.1091/mbc.E14-12-1615 |