Catalytic Analysis of APOBEC3G Involving Real-Time NMR Spectroscopy Reveals Nucleic Acid Determinants for Deamination

APOBEC3G (A3G) is a single-stranded DNA-specific cytidine deaminase that preferentially converts cytidine to uridine at the third position of triplet cytosine (CCC) hotspots. A3G restricts the infectivity of viruses, such as HIV-1, by targeting CCC hotspots scattered through minus DNA strands, rever...

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Detalles Bibliográficos
Autores principales: Kamba, Keisuke, Nagata, Takashi, Katahira, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395183/
https://www.ncbi.nlm.nih.gov/pubmed/25875164
http://dx.doi.org/10.1371/journal.pone.0124142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395183/
https://www.ncbi.nlm.nih.gov/pubmed/25875164
http://dx.doi.org/10.1371/journal.pone.0124142

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