Autophagy modulates the effects of bis-anthracycline WP631 on p53-deficient prostate cancer cells

Treatment of p53-deficient PC-3 human prostate carcinoma cells with nanomolar concentrations of bis-anthracycline WP631 induced changes in gene expression, which resulted in G2/M cell cycle arrest, autophagy and cell death. The presence of 2-deoxy-D-glucose (2-DG), which induces metabolic stress and...

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Detalles Bibliográficos
Autores principales: Mansilla, Sylvia, Vizcaíno, Carolina, Rodríguez-Sánchez, Maria A, Priebe, Waldemar, Portugal, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395193/
https://www.ncbi.nlm.nih.gov/pubmed/25689150
http://dx.doi.org/10.1111/jcmm.12402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395193/
https://www.ncbi.nlm.nih.gov/pubmed/25689150
http://dx.doi.org/10.1111/jcmm.12402

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