Cargando…

Simvastatin Modulates Mesenchymal Stromal Cell Proliferation and Gene Expression

Statins are widely used hypocholesterolemic drugs that block the mevalonate pathway, responsible for the biosysnthesis of cholesterol. However, statins also have pleiotropic effects that interfere with several signaling pathways. Mesenchymal stromal cells (MSC) are a heterogeneous mixture of cells t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zanette, Dalila Lucíola, Lorenzi, Julio Cesar Cetrulo, Panepucci, Rodrigo Alexandre, Palma, Patricia Vianna Bonini, dos Santos, Daiane Fernanda, Prata, Karen Lima, Silva, Wilson Araújo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395223/ https://www.ncbi.nlm.nih.gov/pubmed/25874574 http://dx.doi.org/10.1371/journal.pone.0120137

Ejemplares similares

Osteoblastic differentiation of bone marrow mesenchymal stromal cells in Bruck Syndrome
por: Kaneto, Carla M., et al.
Publicado: (2016)

Highly expressed placental miRNAs control key biological processes in human cancer cell lines
por: Vidal, Daniel Onofre, et al.
Publicado: (2018)

Modulation of Immunoregulatory Properties of Mesenchymal Stromal Cells by Toll-Like Receptors: Potential Applications on GVHD
por: Sangiorgi, Bruno, et al.
Publicado: (2016)

Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line
por: Muys, Bruna Rodrigues, et al.
Publicado: (2016)

Transcriptomic comparisons between cultured human adipose tissue-derived pericytes and mesenchymal stromal cells
por: da Silva Meirelles, Lindolfo, et al.
Publicado: (2015)

LL-37 boosts immunosuppressive function of placenta-derived mesenchymal stromal cells
por: Oliveira-Bravo, Martha, et al.
Publicado: (2016)

Collagenase Impacts the Quantity and Quality of Native Mesenchymal Stem/Stromal Cells Derived during Processing of Umbilical Cord Tissue
por: Taghizadeh, Rouzbeh R., et al.
Publicado: (2018)

Multipotent mesenchymal stromal cells from patients with newly diagnosed type 1 diabetes mellitus exhibit preserved in vitro and in vivo immunomodulatory properties
por: Yaochite, Juliana Navarro Ueda, et al.
Publicado: (2016)

COL1A1 and miR-29b show lower expression levels during osteoblast differentiation of bone marrow stromal cells from Osteogenesis Imperfecta patients
por: Kaneto, Carla M, et al.
Publicado: (2014)

Treatment of experimental periodontal disease by laser therapy in simvastatin-modified rats
por: SWERTS, Andressa Araújo, et al.
Publicado: (2017)

ETV4 plays a role on the primary events during the adenoma-adenocarcinoma progression in colorectal cancer
por: Fonseca, Aline Simoneti, et al.
Publicado: (2021)

Screening of Exosome-Derived Proteins and Their Potential as Biomarkers in Diagnostic and Prognostic for Pancreatic Cancer
por: Marin, Anelis Maria, et al.
Publicado: (2023)

Arrayed functional genetic screenings in pluripotency reprogramming and differentiation
por: Panepucci, Rodrigo Alexandre, et al.
Publicado: (2019)

The Effect of Simvastatin on the Proliferation and Differentiation of Human Bone Marrow Stromal Cells
por: Baek, Ki Hyun, et al.
Publicado: (2005)

Circulating Cell-Free Nucleic Acids as Biomarkers for Diagnosis and Prognosis of Pancreatic Cancer
por: Marin, Anelis Maria, et al.
Publicado: (2023)

Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes: roles of canonical and non-canonical NF-κB signalling
por: Saldanha-Araujo, Felipe, et al.
Publicado: (2012)

Obesity as a Possible Risk Factor for Progression from Monoclonal Gammopathy of Undetermined Significance Progression into Multiple Myeloma: Could Myeloma Be Prevented with Metformin Treatment?
por: da Cunha Júnior, Ademar Dantas, et al.
Publicado: (2021)

Plasma Exosome-Derived microRNAs as Potential Diagnostic and Prognostic Biomarkers in Brazilian Pancreatic Cancer Patients
por: Marin, Anelis Maria, et al.
Publicado: (2022)

Comparison of microRNA expression in high-count monoclonal B-cell lymphocytosis and Binet A chronic lymphocytic leukemia
por: Furtado, Felipe Magalhães, et al.
Publicado: (2017)

Therapeutic efficacy and biodistribution of allogeneic mesenchymal stem cells delivered by intrasplenic and intrapancreatic routes in streptozotocin-induced diabetic mice
por: Yaochite, Juliana Navarro Ueda, et al.
Publicado: (2015)

Simvastatin inhibits POVPC-mediated induction of endothelial-to-mesenchymal cell transition
por: Li, Yan, et al.
Publicado: (2021)

Mechanisms of T-Cell Immunosuppression by Mesenchymal Stromal Cells: What Do We Know So Far?
por: Haddad, Rodrigo, et al.
Publicado: (2014)

GVHD-derived plasma as a priming strategy of mesenchymal stem cells
por: Silva-Carvalho, Amandda Évelin, et al.
Publicado: (2020)

Study of Mesenchymal Stem Cells Cultured on a Poly(Lactic-co-Glycolic Acid) Scaffold Containing Simvastatin for Bone Healing
por: Mendes Junior, Dario, et al.
Publicado: (2017)

Influence of simvastatin on the biological behavior of nucleus pulposus-derived mesenchymal stem cells
por: Huang, Zenan, et al.
Publicado: (2019)

Pleiotropic effects on proliferation and mineralization of primary human adipose tissue-derived stromal cells induced by simvastatin
por: Sabandal, Martin Mariano Isabelo, et al.
Publicado: (2022)

Simvastatin combined with bone marrow mesenchymal stromal cells (BMSCs) improve burn wound healing by ameliorating angiogenesis through SDF-1α/CXCR4 pathway
por: Mohajer Ansari, Javad, et al.
Publicado: (2020)

Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases
por: Silva, Luisa H. A., et al.
Publicado: (2018)

Essential properties and pitfalls of colorimetric Reverse Transcription Loop-mediated Isothermal Amplification as a point-of-care test for SARS-CoV-2 diagnosis
por: de Oliveira Coelho, Bruna, et al.
Publicado: (2021)

Mesenchymal Stromal Cells in Viral Infections: Implications for COVID-19
por: Rocha, José Lucas Martins, et al.
Publicado: (2020)

TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation
por: Schiavinato, Josiane Lilian dos Santos, et al.
Publicado: (2017)

Ezetimibe/simvastatin vs simvastatin in coronary heart disease patients with or without diabetes
por: Rotella, Carlo M, et al.
Publicado: (2010)

Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells
por: Rigoni, Micol, et al.
Publicado: (2015)

Bone marrow-derived mesenchymal stromal cell: what next?
por: Borges, Fernanda T, et al.
Publicado: (2018)

Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells
por: Kim, Kyung Hye, et al.
Publicado: (2012)

Alpha-5 Integrin Mediates Simvastatin-Induced Osteogenesis of Bone Marrow Mesenchymal Stem Cells
por: Shao, Pei-Lin, et al.
Publicado: (2019)

Evaluation of Simvastatin in the Process of Fracture Healing in Tibiae of Rats()
por: Vasconcelos, José Wanderley, et al.
Publicado: (2013)

Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin
por: Campos-Estrada, Carolina, et al.
Publicado: (2015)

Cellophane based mini-prep method for DNA extraction from the filamentous fungus Trichoderma reesei
por: Cassago, Alexandre, et al.
Publicado: (2002)

Antitumor Activity of Simvastatin in Preclinical Models of Mantle Cell Lymphoma
por: Santos, Juliana Carvalho, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_f17p4bklvv1c7298fiqbpc7mv4