The Tyrosine Phosphatase SHP2 Associates with CUB Domain-Containing Protein-1 (CDCP1), Regulating Its Expression at the Cell Surface in a Phosphorylation-Dependent Manner

CUB domain-containing protein-1 (CDCP1) is a transmembrane glycoprotein that is phosphorylated by SRC family kinases (SFK) before recruiting and activating PKCδ. CDCP1 is overproduced in many cancers. It promotes metastasis and resistance to anoïkis. The robust production of CDCP1 would be associate...

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Detalles Bibliográficos
Autores principales: Gandji, Leslie Yewakon, Proust, Richard, Larue, Lionel, Gesbert, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395315/
https://www.ncbi.nlm.nih.gov/pubmed/25876044
http://dx.doi.org/10.1371/journal.pone.0123472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395315/
https://www.ncbi.nlm.nih.gov/pubmed/25876044
http://dx.doi.org/10.1371/journal.pone.0123472

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