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Optogenetic induced epileptiform activity in a model human cortex

BACKGROUND: Cortical stimulation plays an important role in the study of epileptic seizures. We present a numerical simulation of stimulation using optogenetic channels expressed by excitatory cells in a mean field model of the human cortex. FINDINGS: Depolarising excitatory cells in a patch of mode...

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Detalles Bibliográficos
Autores principales: Selvaraj, Prashanth, Sleigh, Jamie W, Kirsch, Heidi E, Szeri, Andrew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395626/
https://www.ncbi.nlm.nih.gov/pubmed/25897410
http://dx.doi.org/10.1186/s40064-015-0836-7