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The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling
The c-Jun/AP-1 transcription factor controls key cellular behaviours, including proliferation and apoptosis, in response to JNK and Ras/MAPK signalling. While the JNK pathway has been well characterised, the mechanism of activation by Ras was elusive. Here we identify the uncharacterised ubiquitin l...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395875/ https://www.ncbi.nlm.nih.gov/pubmed/25851810 http://dx.doi.org/10.1038/ncomms7782 |