IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age

Decline in immune function and inflammation concomitantly develop with ageing. Here we focus on the impact of this inflammatory environment on T cells, and demonstrate that in contrast to successful tumour elimination in young mice, replenishment of tumour-specific CD4(+) T cells fails to induce tum...

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Detalles Bibliográficos
Autores principales: Tsukamoto, Hirotake, Senju, Satoru, Matsumura, Keiko, Swain, Susan L., Nishimura, Yasuharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396369/
https://www.ncbi.nlm.nih.gov/pubmed/25850032
http://dx.doi.org/10.1038/ncomms7702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396369/
https://www.ncbi.nlm.nih.gov/pubmed/25850032
http://dx.doi.org/10.1038/ncomms7702

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