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IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age
Decline in immune function and inflammation concomitantly develop with ageing. Here we focus on the impact of this inflammatory environment on T cells, and demonstrate that in contrast to successful tumour elimination in young mice, replenishment of tumour-specific CD4(+) T cells fails to induce tum...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396369/ https://www.ncbi.nlm.nih.gov/pubmed/25850032 http://dx.doi.org/10.1038/ncomms7702 |