Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms

In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a characteristic pattern of gene expression. Here we quantify the Shh gradient in the developing mouse neural tube and show that while the amplitude of the gradient increases over time, the activity of the pathway transcri...

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Detalles Bibliográficos
Autores principales: Cohen, Michael, Kicheva, Anna, Ribeiro, Ana, Blassberg, Robert, Page, Karen M., Barnes, Chris P., Briscoe, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396374/
https://www.ncbi.nlm.nih.gov/pubmed/25833741
http://dx.doi.org/10.1038/ncomms7709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396374/
https://www.ncbi.nlm.nih.gov/pubmed/25833741
http://dx.doi.org/10.1038/ncomms7709

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