Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production

TRAF6 is critical for the production of inflammatory cytokines in various TLR-mediated signalling pathways. However, it is poorly understood how TRAF6 regulates TLR3 responses. Here we demonstrate that GSK3β interacts with TRAF6 and positively regulates the TLR3-mediated signalling. Suppression of G...

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Detalles Bibliográficos
Autores principales: Ko, Ryeojin, Park, Jin Hee, Ha, Hyunil, Choi, Yongwon, Lee, Soo Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396377/
https://www.ncbi.nlm.nih.gov/pubmed/25828701
http://dx.doi.org/10.1038/ncomms7765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396377/
https://www.ncbi.nlm.nih.gov/pubmed/25828701
http://dx.doi.org/10.1038/ncomms7765

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