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Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production

TRAF6 is critical for the production of inflammatory cytokines in various TLR-mediated signalling pathways. However, it is poorly understood how TRAF6 regulates TLR3 responses. Here we demonstrate that GSK3β interacts with TRAF6 and positively regulates the TLR3-mediated signalling. Suppression of G...

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Detalles Bibliográficos
Autores principales:	Ko, Ryeojin, Park, Jin Hee, Ha, Hyunil, Choi, Yongwon, Lee, Soo Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396377/ https://www.ncbi.nlm.nih.gov/pubmed/25828701 http://dx.doi.org/10.1038/ncomms7765

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