Rosiglitazone attenuates the metalloprotease/anti-metalloprotease imbalance in emphysema induced by cigarette smoke: involvement of extracellular signal-regulated kinase and NFκB signaling

OBJECTIVE: We investigated how rosiglitazone attenuated cigarette smoke (CS)-induced emphysema in a rat model. In particular, we focused on its possible effects on the imbalance between metalloprotease (MMP) and anti-MMP activity, mitogen-activated protein kinase (MAPK) phosphorylation, and nuclear...

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Detalles Bibliográficos
Autores principales: Hou, Gang, Yin, Yan, Han, Dan, Wang, Qiu-yue, Kang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396520/
https://www.ncbi.nlm.nih.gov/pubmed/25897215
http://dx.doi.org/10.2147/COPD.S77514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396520/
https://www.ncbi.nlm.nih.gov/pubmed/25897215
http://dx.doi.org/10.2147/COPD.S77514

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