Structure and Dynamics of the Integrin LFA-1 I-Domain in the Inactive State Underlie its Inside-Out/Outside-In Signaling and Allosteric Mechanisms

Lymphocyte function-associated antigen 1 (LFA-1) is an integrin that transmits information in two directions across the plasma membrane of leukocytes, in so-called outside-in and inside-out signaling mechanisms. To investigate the structural basis of these mechanisms, we studied the conformational s...

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Detalles Bibliográficos
Autores principales: Kukic, Predrag, Alvin Leung, Hoi Tik, Bemporad, Francesco, Aprile, Francesco A., Kumita, Janet R., De Simone, Alfonso, Camilloni, Carlo, Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396694/
https://www.ncbi.nlm.nih.gov/pubmed/25773142
http://dx.doi.org/10.1016/j.str.2014.12.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396694/
https://www.ncbi.nlm.nih.gov/pubmed/25773142
http://dx.doi.org/10.1016/j.str.2014.12.020

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