Anti-Diabetes Drug Pioglitazone Ameliorates Synaptic Defects in AD Transgenic Mice by Inhibiting Cyclin-Dependent Kinase5 Activity

Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is activated by the neuron specific activators p35/p39 and plays many important roles in neuronal development. However, aberrant activation of Cdk5 is believed to be associated with the pathogenesis of several neurodegenerative disea...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Jinan, Li, Shenghua, Sun, Wenshan, Li, Junrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396851/
https://www.ncbi.nlm.nih.gov/pubmed/25875370
http://dx.doi.org/10.1371/journal.pone.0123864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396851/
https://www.ncbi.nlm.nih.gov/pubmed/25875370
http://dx.doi.org/10.1371/journal.pone.0123864

Ejemplares similares