Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring

BACKGROUND: The prevalence of some autoimmune diseases is greater in females compared with males, although disease severity is often greater in males. The reason for this sexual dimorphism is unknown, but it may reflect negative selection of Y chromosome-bearing sperm during spermatogenesis or male...

Descripción completa

Detalles Bibliográficos
Autores principales: Case, Laure K, Wall, Emma H, Osmanski, Erin E, Dragon, Julie A, Saligrama, Naresha, Zachary, James F, Lemos, Bernardo, Blankenhorn, Elizabeth P, Teuscher, Cory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396973/
https://www.ncbi.nlm.nih.gov/pubmed/25886764
http://dx.doi.org/10.1186/s13059-015-0591-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396973/
https://www.ncbi.nlm.nih.gov/pubmed/25886764
http://dx.doi.org/10.1186/s13059-015-0591-7

Ejemplares similares