Immunizations with hepatitis B viral antigens and a TLR7/8 agonist adjuvant induce antigen-specific immune responses in HBV-transgenic mice

BACKGROUND: The capacity of toll-like receptor (TLR) 7/8 agonist-conjugated hepatitis B virus (HBV) proteins (HBV-Ag) to overcome established hepatitis B surface antigen (HBsAg)-specific immune tolerance was explored. METHODS: A TLR7/8 agonist, CL097, was conjugated with alum-absorbed HBsAg and hepa...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Chen, Kun, Wu, Zhiyuan, Liu, Yuetao, Liu, Shangmei, Zou, Zhongmei, Chen, Shu-Hsia, Qu, Chunfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397646/
https://www.ncbi.nlm.nih.gov/pubmed/25449231
http://dx.doi.org/10.1016/j.ijid.2014.07.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397646/
https://www.ncbi.nlm.nih.gov/pubmed/25449231
http://dx.doi.org/10.1016/j.ijid.2014.07.015

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