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Immunizations with hepatitis B viral antigens and a TLR7/8 agonist adjuvant induce antigen-specific immune responses in HBV-transgenic mice

BACKGROUND: The capacity of toll-like receptor (TLR) 7/8 agonist-conjugated hepatitis B virus (HBV) proteins (HBV-Ag) to overcome established hepatitis B surface antigen (HBsAg)-specific immune tolerance was explored. METHODS: A TLR7/8 agonist, CL097, was conjugated with alum-absorbed HBsAg and hepa...

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Detalles Bibliográficos
Autores principales:	Wang, Ying, Chen, Kun, Wu, Zhiyuan, Liu, Yuetao, Liu, Shangmei, Zou, Zhongmei, Chen, Shu-Hsia, Qu, Chunfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397646/ https://www.ncbi.nlm.nih.gov/pubmed/25449231 http://dx.doi.org/10.1016/j.ijid.2014.07.015

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