Caspase-2 is required for dendritic spine and behavioral alterations in J20 APP transgenic mice

Caspases play critical roles in Alzheimer’s disease (AD) pathogenesis. Here we show that caspase-2 is required for the cognitive decline seen in hAPP transgenic mice (J20). The age-related changes in behavior and dendritic spine density observed in these mice are absent when they lack caspase-2, in...

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Detalles Bibliográficos
Autores principales: Pozueta, Julio, Lefort, Roger, Ribe, Elena M., Troy, Carol M., Aran-cio, Ottavio, Shelanski, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398315/
https://www.ncbi.nlm.nih.gov/pubmed/23748737
http://dx.doi.org/10.1038/ncomms2927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398315/
https://www.ncbi.nlm.nih.gov/pubmed/23748737
http://dx.doi.org/10.1038/ncomms2927

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