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Caspase-2 is required for dendritic spine and behavioral alterations in J20 APP transgenic mice
Caspases play critical roles in Alzheimer’s disease (AD) pathogenesis. Here we show that caspase-2 is required for the cognitive decline seen in hAPP transgenic mice (J20). The age-related changes in behavior and dendritic spine density observed in these mice are absent when they lack caspase-2, in...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398315/ https://www.ncbi.nlm.nih.gov/pubmed/23748737 http://dx.doi.org/10.1038/ncomms2927 |