Cargando…

Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease

Hepatitis C virus (HCV) non-structural 2 (NS2) encodes an essential protease activity responsible for processing at the NS2–NS3 junction which represents an attractive antiviral target. Attempts to inhibit the NS2 autoprotease with mechanism-based protease inhibitors and substrate peptides have had...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shaw, Joseph, Fishwick, Colin W.G., Harris, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398321/ https://www.ncbi.nlm.nih.gov/pubmed/25703928 http://dx.doi.org/10.1016/j.antiviral.2015.02.005

Ejemplares similares

Identification of a lead like inhibitor of the hepatitis C virus non-structural NS2 autoprotease
por: Shaw, Joseph, et al.
Publicado: (2015)

A comparative analysis of the fluorescence properties of the wild-type and active site mutants of the hepatitis C virus autoprotease NS2-3
por: Foster, Toshana L., et al.
Publicado: (2010)

The Structure of Classical Swine Fever Virus N(pro): A Novel Cysteine Autoprotease and Zinc-Binding Protein Involved in Subversion of Type I Interferon Induction
por: Gottipati, Keerthi, et al.
Publicado: (2013)

Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated K(Na)1.1 (KCNT1) Potassium Channel
por: Cole, Bethan A., et al.
Publicado: (2020)

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
por: Grossman, Scott, et al.
Publicado: (2023)

Effects of Individual Circulating FFAs on Plasma and Hepatic FFA Epoxides, Diols, and Epoxide-Diol Ratios as Indices of Soluble Epoxide Hydrolase Activity
por: Oh, Young Taek, et al.
Publicado: (2023)

Visualisation and analysis of hepatitis C virus non-structural proteins using super-resolution microscopy
por: Bartlett, Christopher, et al.
Publicado: (2018)

Identification of a small molecule inhibitor of Ebola virus genome replication and transcription using in silico screening
por: Easton, Victoria, et al.
Publicado: (2018)

Epoxide resins
por: Potter, W G
Publicado: (1970)

Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine
por: Shihadih, Diyala S., et al.
Publicado: (2020)

Effect of Epoxide Content on the Vulcanizate Structure of Silica-Filled Epoxidized Natural Rubber (ENR) Compounds
por: Ryu, Gyeongchan, et al.
Publicado: (2021)

In Silico Modeling and Structural Analysis of Soluble Epoxide Hydrolase Inhibitors for Enhanced Therapeutic Design
por: Sar, Shuvam, et al.
Publicado: (2023)

Editorial: Clinical Paths for Soluble Epoxide Hydrolase Inhibitors
por: Imig, John D., et al.
Publicado: (2020)

The role of soluble epoxide hydrolase and its inhibitors in depression
por: Borsini, Alessandra
Publicado: (2021)

Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales
por: Kitamura, Seiya, et al.
Publicado: (2017)

The crystal structure of mycobacterial epoxide hydrolase A
por: Schulz, Eike C., et al.
Publicado: (2020)

Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain
por: Du, Fangyu, et al.
Publicado: (2022)

Structure-Guided Design Affirms Inhibitors of Hepatitis C Virus p7 as a Viable Class of Antivirals Targeting Virion Release
por: Foster, Toshana L, et al.
Publicado: (2014)

Epoxides and their derivatives
por: Malinovskii, M S
Publicado: (1965)

Discovery of Novel Soluble Epoxide Hydrolase Inhibitors as Potent Vasodilators
por: Tripathi, Neetika, et al.
Publicado: (2018)

Soluble epoxide hydrolase inhibitor promotes the healing of oral ulcers
por: Li, Juanjuan, et al.
Publicado: (2023)

Hepatitis C virus and hepatitis B virus in patients with schizophrenia
por: Chang, Chun-Hung, et al.
Publicado: (2021)

Catalytic developments in the epoxidation of vegetable oils and the analysis methods of epoxidized products
por: Wai, Phyu Thin, et al.
Publicado: (2019)

A novel method for the measurement of hepatitis C virus infectious titres using the IncuCyte ZOOM and its application to antiviral screening
por: Stewart, Hazel, et al.
Publicado: (2015)

Vascular repair and anti-inflammatory effects of soluble epoxide hydrolase inhibitor
por: Dai, Na, et al.
Publicado: (2019)

The Soluble Epoxide Hydrolase Inhibitor AR9281 Decreases Blood Pressure, Ameliorates Renal Injury and Improves Vascular Function in Hypertension
por: Imig, John D., et al.
Publicado: (2009)

A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry
por: Baldick, Carl J., et al.
Publicado: (2010)

The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein
por: Tedbury, Philip, et al.
Publicado: (2011)

Hydroxy-epoxide and keto-epoxide derivatives of linoleic acid activate trigeminal neurons
por: Doolen, Suzanne, et al.
Publicado: (2020)

Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease
por: Mello, Aline, et al.
Publicado: (2020)

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy
por: Shaw, Joseph, et al.
Publicado: (2020)

The Therapeutic Approaches for Hepatitis C Virus: Protease Inhibitors and Polymerase Inhibitors
por: Kwo, Paul Y., et al.
Publicado: (2011)

NS2 Protein of Hepatitis C Virus Interacts with Structural and Non-Structural Proteins towards Virus Assembly
por: Popescu, Costin-Ioan, et al.
Publicado: (2011)

Protease inhibitors for the treatment of hepatitis C virus infection
por: de Leuw, Philipp, et al.
Publicado: (2017)

Structure of a bacterial homolog of vitamin K epoxide reductase
por: Li, Weikai, et al.
Publicado: (2010)

Structural Insights of Humins/Epoxidized Linseed Oil/ Hardener Terpolymerization
por: Licsandru, Erol, et al.
Publicado: (2020)

Identification of Novel Small Molecules as Inhibitors of Hepatitis C Virus by Structure-Based Virtual Screening
por: Li, Jing, et al.
Publicado: (2013)

Structure-function relationship between soluble epoxide hydrolases structure and their tunnel network
por: Mitusińska, Karolina, et al.
Publicado: (2021)

Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers
por: Yang, Lucy, et al.
Publicado: (2017)

Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA
por: Yang, Huiyi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_n01hkrhcg75svf2e333i6a9vce