Calpain Inhibitor PD150606 Attenuates Glutamate Induced Spiral Ganglion Neuron Apoptosis through Apoptosis Inducing Factor Pathway In Vitro

OBJECTIVE: This research aimed to investigate whether glutamate induced spiral ganglion neurons (SGNs) apoptosis through apoptosis inducing factor (AIF) pathway. And verify whether PD150606, a calpain inhibitor could prevent apoptosis by inhibiting cleaving and releasing AIF in mitochondrion. METHOD...

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Detalles Bibliográficos
Autores principales: Ding, Zhong-Jia, Chen, Xin, Tang, Xiao-Xu, Wang, Xi, Song, Yong-Li, Chen, Xiao-Dong, Mi, Wen-Juan, Wang, Jian, Lin, Ying, Chen, Fu-Quan, Qiu, Jian-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398365/
https://www.ncbi.nlm.nih.gov/pubmed/25874633
http://dx.doi.org/10.1371/journal.pone.0123130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398365/
https://www.ncbi.nlm.nih.gov/pubmed/25874633
http://dx.doi.org/10.1371/journal.pone.0123130

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