Preferential Targeting of Na(v)1.6 Voltage-Gated Na(+) Channels to the Axon Initial Segment during Development

During axonal maturation, voltage-gated sodium (Na(v)) channels accumulate at the axon initial segment (AIS) at high concentrations. This localization is necessary for the efficient initiation of action potentials. The mechanisms underlying channel trafficking to the AIS during axonal development ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Akin, Elizabeth J., Solé, Laura, Dib-Hajj, Sulayman D., Waxman, Stephen G., Tamkun, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398423/
https://www.ncbi.nlm.nih.gov/pubmed/25874799
http://dx.doi.org/10.1371/journal.pone.0124397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398423/
https://www.ncbi.nlm.nih.gov/pubmed/25874799
http://dx.doi.org/10.1371/journal.pone.0124397

Ejemplares similares