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Role of the EHD2 Unstructured Loop in Dimerization, Protein Binding and Subcellular Localization

The C-terminal Eps 15 Homology Domain proteins (EHD1-4) play important roles in regulating endocytic trafficking. EHD2 is the only family member whose crystal structure has been solved, and it contains an unstructured loop consisting of two proline-phenylalanine (PF) motifs: KPFRKLNPF. In contrast,...

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Detalles Bibliográficos
Autores principales: Bahl, Kriti, Naslavsky, Naava, Caplan, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398442/
https://www.ncbi.nlm.nih.gov/pubmed/25875965
http://dx.doi.org/10.1371/journal.pone.0123710