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Evolution of the Perlecan/HSPG2 Gene and Its Activation in Regenerating Nematostella vectensis

The heparan sulfate proteoglycan 2 (HSPG2)/perlecan gene is ancient and conserved in all triploblastic species. Its presence maintains critical cell boundaries in tissue and its large (up to ~900 kDa) modular structure has prompted speculation about the evolutionary origin of the gene. The gene’s co...

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Detalles Bibliográficos
Autores principales: Warren, Curtis R., Kassir, Elias, Spurlin, James, Martinez, Jerahme, Putnam, Nicholas H., Farach-Carson, Mary C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398486/
https://www.ncbi.nlm.nih.gov/pubmed/25876075
http://dx.doi.org/10.1371/journal.pone.0124578