ABCC6 deficiency is associated with activation of BMP signaling in liver and kidney

Mutations in ABCC6 (ATP-binding cassette, subfamily C, member 6), an orphan transporter expressed in the liver, are the cause of pseudoxanthoma elasticum. Since ABCC6 was reported to affect matrix Gla protein (MGP), an inhibitor of bone morphogenetic proteins (BMPs), we studied BMP signaling and exp...

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Detalles Bibliográficos
Autores principales: Blazquez-Medela, Ana M., Guihard, Pierre J., Yao, Jiayi, Jumabay, Medet, Lusis, Aldons J., Boström, Kristina I., Yao, Yucheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398664/
https://www.ncbi.nlm.nih.gov/pubmed/25893161
http://dx.doi.org/10.1016/j.fob.2015.03.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398664/
https://www.ncbi.nlm.nih.gov/pubmed/25893161
http://dx.doi.org/10.1016/j.fob.2015.03.009

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