Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy through the generation of nitric oxide

Autophagy is one of the major causes of drug resistance. For example, the angiogenesis inhibitor bevacizumab shows only transient and short-term therapeutic effects, whereas long-term therapeutic benefits are rarely observed, probably due to hypoxia-induced autophagy. Nitric oxide (NO) is an importa...

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Detalles Bibliográficos
Autores principales: Ishima, Yu, Inoue, Aki, Fang, Jun, Kinoshita, Ryo, Ikeda, Mayumi, Watanabe, Hiroshi, Maeda, Hiroshi, Otagiri, Masaki, Maruyama, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399024/
https://www.ncbi.nlm.nih.gov/pubmed/25457681
http://dx.doi.org/10.1111/cas.12577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399024/
https://www.ncbi.nlm.nih.gov/pubmed/25457681
http://dx.doi.org/10.1111/cas.12577

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