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Titration of biologically active amyloid–β seeds in a transgenic mouse model of Alzheimer's disease
Experimental evidence in animal models suggests that misfolded Amyloid-β (Aβ) spreads in disease following a prion-like mechanism. Several properties characteristics of infectious prions have been shown for the induction of Aβ aggregates. However, a detailed titration of Aβ misfolding transmissibili...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399520/ https://www.ncbi.nlm.nih.gov/pubmed/25879692 http://dx.doi.org/10.1038/srep09349 |