Denoising perturbation signatures reveal an actionable AKT-signaling gene module underlying a poor clinical outcome in endocrine-treated ER+ breast cancer

BACKGROUND: Databases of perturbation gene expression signatures and drug sensitivity provide a powerful framework to develop personalized medicine approaches, by helping to identify actionable genomic markers and subgroups of patients who may benefit from targeted treatments. RESULTS: Here we use a...

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Detalles Bibliográficos
Autores principales: Teschendorff, Andrew E, Li, Linlin, Yang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399757/
https://www.ncbi.nlm.nih.gov/pubmed/25886003
http://dx.doi.org/10.1186/s13059-015-0630-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399757/
https://www.ncbi.nlm.nih.gov/pubmed/25886003
http://dx.doi.org/10.1186/s13059-015-0630-4

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