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Mechanisms Contributing to Differential Regulation of PAX3 Downstream Target Genes in Normal Human Epidermal Melanocytes versus Melanoma Cells

Melanoma is a highly aggressive and drug resistant form of skin cancer. It arises from melanocytes, the pigment producing cells of the skin. The formation of these melanocytes is driven by the transcription factor PAX3 early during embryonic development. As a result of alternative splicing, the PAX3...

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Detalles Bibliográficos
Autores principales: Bartlett, Danielle, Boyle, Glen M., Ziman, Mel, Medic, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399949/
https://www.ncbi.nlm.nih.gov/pubmed/25880082
http://dx.doi.org/10.1371/journal.pone.0124154