Molecular Determinants for Recognition of Divergent SAMHD1 Proteins by the Lentiviral Accessory Protein Vpx

The SAMHD1 triphosphohydrolase inhibits HIV-1 infection of myeloid and resting T cells by depleting dNTPs. To overcome SAMHD1, HIV-2 and some SIVs encode either of two lineages of the accessory protein Vpx that bind the SAMHD1 N or C terminus and redirect the host cullin-4 ubiquitin ligase to target...

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Detalles Bibliográficos
Autores principales: Schwefel, David, Boucherit, Virginie C., Christodoulou, Evangelos, Walker, Philip A., Stoye, Jonathan P., Bishop, Kate N., Taylor, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400269/
https://www.ncbi.nlm.nih.gov/pubmed/25856754
http://dx.doi.org/10.1016/j.chom.2015.03.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400269/
https://www.ncbi.nlm.nih.gov/pubmed/25856754
http://dx.doi.org/10.1016/j.chom.2015.03.004

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