HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs

Fiber type-specific programs controlled by the transcription factor MEF2 dictate muscle functionality. Here, we show that HDAC4, a potent MEF2 inhibitor, is predominantly localized to the nuclei in fast/glycolytic fibers in contrast to the sarcoplasm in slow/oxidative fibers. The cytoplasmic localiz...

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Detalles Bibliográficos
Autores principales: Cohen, Todd J., Choi, Moon-Chang, Kapur, Meghan, Lira, Vitor A., Yan, Zhen, Yao, Tso-Pang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400309/
https://www.ncbi.nlm.nih.gov/pubmed/25728750
http://dx.doi.org/10.14348/molcells.2015.2278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400309/
https://www.ncbi.nlm.nih.gov/pubmed/25728750
http://dx.doi.org/10.14348/molcells.2015.2278

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