Increased expression of renal TRPM6 compensates for Mg(2+) wasting during furosemide treatment

BACKGROUND: Furosemide is a loop diuretic, which blocks the Na(+), K(+), 2Cl(−) cotransporter (NKCC2) in the thick ascending limb of Henle (TAL). By diminishing sodium (Na(+)) reabsorption, loop diuretics reduce the lumen-positive transepithelial voltage and consequently diminish paracellular transp...

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Detalles Bibliográficos
Autores principales: van Angelen, Annelies A., van der Kemp, AnneMiete W., Hoenderop, Joost G., Bindels, René J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400563/
https://www.ncbi.nlm.nih.gov/pubmed/26069797
http://dx.doi.org/10.1093/ckj/sfs140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400563/
https://www.ncbi.nlm.nih.gov/pubmed/26069797
http://dx.doi.org/10.1093/ckj/sfs140

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