Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway

The KDM4 family of lysine demethylases consists of five members, KDM4A, -B and -C that demethylate H3K9me2/3 and H3K36me2/3 marks, while KDM4D and -E demethylate only H3K9me2/3. Recent studies implicated KDM4 proteins in regulating genomic instability and carcinogenesis. Here, we describe a previous...

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Detalles Bibliográficos
Autores principales: Awwad, Samah W., Ayoub, Nabieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400592/
https://www.ncbi.nlm.nih.gov/pubmed/25770186
http://dx.doi.org/10.1242/bio.201410991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400592/
https://www.ncbi.nlm.nih.gov/pubmed/25770186
http://dx.doi.org/10.1242/bio.201410991

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