Cargando…

A Non-invasive Platform for Functional Characterization of Stem-Cell-Derived Cardiomyocytes with Applications in Cardiotoxicity Testing

We present a non-invasive method to characterize the function of pluripotent stem-cell-derived cardiomyocytes based on video microscopy and image analysis. The platform, called Pulse, generates automated measurements of beating frequency, beat duration, amplitude, and beat-to-beat variation based on...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maddah, Mahnaz, Heidmann, Julia D., Mandegar, Mohammad A., Walker, Chase D., Bolouki, Sara, Conklin, Bruce R., Loewke, Kevin E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400609/ https://www.ncbi.nlm.nih.gov/pubmed/25801505 http://dx.doi.org/10.1016/j.stemcr.2015.02.007

Ejemplares similares

Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes
por: Grafton, Francis, et al.
Publicado: (2021)

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes
por: Maillet, Agnes, et al.
Publicado: (2016)

Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes
por: Huang, Mo-Fan, et al.
Publicado: (2021)

Automated image analysis system for studying cardiotoxicity in human pluripotent stem cell-Derived cardiomyocytes
por: Cao, Lu, et al.
Publicado: (2020)

Modelling cadmium‐induced cardiotoxicity using human pluripotent stem cell‐derived cardiomyocytes
por: Shen, Jiaxi, et al.
Publicado: (2018)

Human Pluripotent Stem Cell-Derived Cardiomyocytes for Assessment of Anticancer Drug-Induced Cardiotoxicity
por: Schwach, Verena, et al.
Publicado: (2020)

Liensinine- and Neferine-Induced Cardiotoxicity in Primary Neonatal Rat Cardiomyocytes and Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
por: Yu, Yangyang, et al.
Publicado: (2016)

Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes
por: Zhao, Qi, et al.
Publicado: (2017)

Cardiotoxicity induced by the combination therapy of chloroquine and azithromycin in human embryonic stem cell-derived cardiomyocytes
por: Kim, Ye Seul, et al.
Publicado: (2020)

Development and evaluation of next-generation cardiotoxicity assay based on embryonic stem cell-derived cardiomyocytes
por: Ryu, Bokyeong, et al.
Publicado: (2020)

Evaluation of the Cardiotoxicity of Mitragynine and Its Analogues Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
por: Lu, Jun, et al.
Publicado: (2014)

Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2017)

Losartan protects human stem cell-derived cardiomyocytes from angiotensin II-induced alcoholic cardiotoxicity
por: Song, Yuanxiu, et al.
Publicado: (2022)

Melphalan induces cardiotoxicity through oxidative stress in cardiomyocytes derived from human induced pluripotent stem cells
por: Liu, Rui, et al.
Publicado: (2020)

Cardiotoxicity and Heart Failure: Lessons from Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Anticancer Drugs
por: Sachinidis, Agapios
Publicado: (2020)

Chronic Cardiotoxicity Assays Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs)
por: Narkar, Akshay, et al.
Publicado: (2022)

Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity
por: Ma, Wanjun, et al.
Publicado: (2020)

Cardiomyocyte Atrophy, an Underestimated Contributor in Doxorubicin-Induced Cardiotoxicity
por: Chen, De-Shu, et al.
Publicado: (2022)

An integrated characterization of contractile, electrophysiological, and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes
por: Wang, Ruiying, et al.
Publicado: (2019)

Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cell-derived cardiomyocytes
por: Christidi, Effimia, et al.
Publicado: (2020)

Characterization of the molecular mechanisms underlying azithromycin‐induced cardiotoxicity using human‐induced pluripotent stem cell‐derived cardiomyocytes
por: Wang, Xiaochen, et al.
Publicado: (2021)

Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Predict the Cardiotoxicity Potential of Next Generation Nicotine Products
por: Simms, Liam, et al.
Publicado: (2022)

Biowire: a new platform for maturation of human pluripotent stem cell derived cardiomyocytes
por: Nunes, Sara S., et al.
Publicado: (2013)

Electrophysiological mechanisms of vandetanib-induced cardiotoxicity: Comparison of action potentials in rabbit Purkinje fibers and pluripotent stem cell-derived cardiomyocytes
por: Lee, Hyang-Ae, et al.
Publicado: (2018)

Correction: An integrated characterization of contractile, electrophysiological and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes
por: Wang, Ruiying, et al.
Publicado: (2023)

Human pluripotent stem cell-derived cardiomyocytes as a target platform for paracrine protection by cardiac mesenchymal stromal cells
por: Constantinou, Chrystalla, et al.
Publicado: (2020)

Echinochrome A Protects Mitochondrial Function in Cardiomyocytes against Cardiotoxic Drugs
por: Jeong, Seung Hun, et al.
Publicado: (2014)

Anthracycline-Induced Cardiotoxicity: Molecular Insights Obtained from Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC-CMs)
por: Bozza, William P., et al.
Publicado: (2021)

Investigating and Resolving Cardiotoxicity Induced by COVID‐19 Treatments using Human Pluripotent Stem Cell‐Derived Cardiomyocytes and Engineered Heart Tissues
por: Xu, He, et al.
Publicado: (2022)

An efficient human stem cells derived cardiotoxicity testing platform for testing oncotherapeutic analogues of quercetin and cinnamic acid
por: Mandal, Saurabh, et al.
Publicado: (2022)

Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes
por: Knowles, David A, et al.
Publicado: (2018)

Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity
por: Guo, Rui, et al.
Publicado: (2018)

Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes
por: Zhao, Liqun, et al.
Publicado: (2017)

CIRBP-OGFR axis safeguards against cardiomyocyte apoptosis and cardiotoxicity induced by chemotherapy
por: Liu, Cihang, et al.
Publicado: (2022)

Role of non-cardiomyocytes in anticancer drug-induced cardiotoxicity: A systematic review
por: Xie, Suifen, et al.
Publicado: (2022)

Cinnamaldehyde alleviates doxorubicin-induced cardiotoxicity by decreasing oxidative stress and ferroptosis in cardiomyocytes
por: Mao, Meijiao, et al.
Publicado: (2023)

Doxorubicin‐induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIα to IIβ in human stem cell derived cardiomyocytes
por: Cui, Ning, et al.
Publicado: (2019)

Doxorubicin-induced cardiotoxicity enhance SARS-CoV-2 infection susceptibility in human cardiomyocytes
por: Lazzarini, Edoardo, et al.
Publicado: (2022)

The virtual heart as a platform for screening drug cardiotoxicity
por: Yuan, Yongfeng, et al.
Publicado: (2015)

Structural Phenotyping of Stem Cell-Derived Cardiomyocytes
por: Pasqualini, Francesco Silvio, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ir86f5ic0q66lb017bg1bfipmq