The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential

Cancer stem cells (CSC) are responsible for cancer chemoresistance and metastasis formation. Here we report that Δ133p53β, a TP53 splice variant, enhanced cancer cell stemness in MCF-7 breast cancer cells, while its depletion reduced it. Δ133p53β stimulated the expression of the key pluripotency fac...

Descripción completa

Detalles Bibliográficos
Autores principales: Arsic, Nikola, Gadea, Gilles, Lagerqvist, E. Louise, Busson, Muriel, Cahuzac, Nathalie, Brock, Carsten, Hollande, Frederic, Gire, Veronique, Pannequin, Julie, Roux, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400643/
https://www.ncbi.nlm.nih.gov/pubmed/25754205
http://dx.doi.org/10.1016/j.stemcr.2015.02.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400643/
https://www.ncbi.nlm.nih.gov/pubmed/25754205
http://dx.doi.org/10.1016/j.stemcr.2015.02.001

Ejemplares similares