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The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential

Cancer stem cells (CSC) are responsible for cancer chemoresistance and metastasis formation. Here we report that Δ133p53β, a TP53 splice variant, enhanced cancer cell stemness in MCF-7 breast cancer cells, while its depletion reduced it. Δ133p53β stimulated the expression of the key pluripotency fac...

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Detalles Bibliográficos
Autores principales:	Arsic, Nikola, Gadea, Gilles, Lagerqvist, E. Louise, Busson, Muriel, Cahuzac, Nathalie, Brock, Carsten, Hollande, Frederic, Gire, Veronique, Pannequin, Julie, Roux, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400643/ https://www.ncbi.nlm.nih.gov/pubmed/25754205 http://dx.doi.org/10.1016/j.stemcr.2015.02.001

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