Alterations in Ovarian Cancer Cell Adhesion Drive Taxol Resistance by Increasing Microtubule Dynamics in a FAK-dependent Manner

Chemorefractory ovarian cancer patients show extremely poor prognosis. Microtubule-stabilizing Taxol (paclitaxel) is a first-line treatment against ovarian cancer. Despite the close interplay between microtubules and cell adhesion, it remains unknown if chemoresistance alters the way cells adhere to...

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Detalles Bibliográficos
Autores principales: McGrail, Daniel J., Khambhati, Niti N., Qi, Mark X., Patel, Krishan S., Ravikumar, Nithin, Brandenburg, Chandler P., Dawson, Michelle R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400875/
https://www.ncbi.nlm.nih.gov/pubmed/25886093
http://dx.doi.org/10.1038/srep09529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400875/
https://www.ncbi.nlm.nih.gov/pubmed/25886093
http://dx.doi.org/10.1038/srep09529

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