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Intra and extravascular transmembrane signalling of angiopoietin-1-Tie2 receptor in health and disease
Angiopoietin-1 (Ang-1) is the primary agonist for Tie2 tyrosine kinase receptor (Tie2), and the effect of Ang-1-Tie2 signalling is context-dependent. Deficiency in either Ang-1 or Tie2 protein leads to severe microvascular defects and subsequent embryonic lethality in murine model. Tie2 receptors ar...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Blackwell Publishing Ltd
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401129/ https://www.ncbi.nlm.nih.gov/pubmed/18266978 http://dx.doi.org/10.1111/j.1582-4934.2008.00254.x |