Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

Oxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD). Both AD and arguably its earlier form, mild cognitive impairment (MCI), have elevated membrane oxidative damage in brain. The tumor suppressor and transcription factor p53 plays a pivotal function in neuronal...

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Detalles Bibliográficos
Autores principales: Cenini, Giovanna, Sultana, Rukhsana, Memo, Maurizio, Butterfield, D Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401131/
https://www.ncbi.nlm.nih.gov/pubmed/18494939
http://dx.doi.org/10.1111/j.1582-4934.2008.00163.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401131/
https://www.ncbi.nlm.nih.gov/pubmed/18494939
http://dx.doi.org/10.1111/j.1582-4934.2008.00163.x

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