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Functional effects of caloxin 1c2, a novel engineered selective inhibitor of plasma membrane Ca(2+)-pump isoform 4, on coronary artery

Coronary artery smooth muscle expresses the plasma membrane Ca(2+) pump (PMCA) isoforms PMCA4 and PMCA1. We previously reported the peptide inhibitor caloxin 1b1 that was obtained by using extracellular domain 1 of PMCA4 as the target (Am J Physiol Cell.290 [2006] C1341). To engineer inhibitors with...

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Detalles Bibliográficos
Autores principales: Pande, Jyoti, Szewczyk, Magdalena M, Kuszczak, Iwona, Grover, Shawn, Escher, E, Grover, Ashok K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401146/
https://www.ncbi.nlm.nih.gov/pubmed/18494944
http://dx.doi.org/10.1111/j.1582-4934.2008.00140.x