The p53(R172H) Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression

Hepatocellular carcinoma is a highly deadly malignancy, accounting for approximately 800,000 deaths worldwide every year. Mutation of the p53 tumor suppressor gene is a common genetic change in HCC, present in 30% of cases. p53(R175H) (corresponding to p53(R172H) in mice) is a hotspot for mutation t...

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Detalles Bibliográficos
Autores principales: Ahronian, Leanne G., Driscoll, David R., Klimstra, David S., Lewis, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401698/
https://www.ncbi.nlm.nih.gov/pubmed/25885474
http://dx.doi.org/10.1371/journal.pone.0123816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401698/
https://www.ncbi.nlm.nih.gov/pubmed/25885474
http://dx.doi.org/10.1371/journal.pone.0123816

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