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The p53(R172H) Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression
Hepatocellular carcinoma is a highly deadly malignancy, accounting for approximately 800,000 deaths worldwide every year. Mutation of the p53 tumor suppressor gene is a common genetic change in HCC, present in 30% of cases. p53(R175H) (corresponding to p53(R172H) in mice) is a hotspot for mutation t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401698/ https://www.ncbi.nlm.nih.gov/pubmed/25885474 http://dx.doi.org/10.1371/journal.pone.0123816 |