Cargando…

Na(+)/H(+) Exchanger Isoform 1-Induced Osteopontin Expression Facilitates Cardiomyocyte Hypertrophy

Enhanced expression and activity of the Na(+)/H(+) exchanger isoform 1 (NHE1) has been implicated in cardiomyocyte hypertrophy in various experimental models. The upregulation of NHE1 was correlated with an increase in osteopontin (OPN) expression in models of cardiac hypertrophy (CH), and the mecha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mohamed, Iman A., Gadeau, Alain-Pierre, Fliegel, Larry, Lopaschuk, Gary, Mlih, Mohamed, Abdulrahman, Nabeel, Fillmore, Natasha, Mraiche, Fatima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401699/ https://www.ncbi.nlm.nih.gov/pubmed/25884410 http://dx.doi.org/10.1371/journal.pone.0123318

Ejemplares similares

Na(+)/H(+) Exchanger Isoform 1 Induced Cardiomyocyte Hypertrophy Involves Activation of p90 Ribosomal S6 Kinase
por: Jaballah, Maiy, et al.
Publicado: (2015)

Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis
por: Abdelaziz Mohamed, Iman, et al.
Publicado: (2019)

Structural and Functional Changes in the Na(+)/H(+) Exchanger Isoform 1, Induced by Erk1/2 Phosphorylation
por: Fliegel, Larry
Publicado: (2019)

The Na(+)/H(+) exchanger in metastasis
por: Amith, Schammim Ray, et al.
Publicado: (2016)

Roles of the Na(+)/H(+) Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion
por: Li, Xiuju, et al.
Publicado: (2021)

Empagliflozin inhibits angiotensin II-induced hypertrophy in H9c2 cardiomyoblasts through inhibition of NHE1 expression
por: Abdulrahman, Nabeel, et al.
Publicado: (2022)

Amino Acids 563–566 of the Na(+)/H(+) Exchanger Isoform 1 C-Terminal Cytosolic Tail Prevent Protein Degradation and Stabilize Protein Expression and Activity
por: Li, Xiuju, et al.
Publicado: (2020)

Evaluating the effects of sodium glucose co-transporter -2 inhibitors from a renin–angiotensin–aldosterone system perspective in patients infected with COVID-19: contextualizing findings from the dapagliflozin in respiratory failure in patients with COVID-19 study
por: Moustafa, Diala Alhaj, et al.
Publicado: (2022)

Assessing Na(+)/H(+) exchange and cell effector functionality in metastatic breast cancer
por: Amith, Schammim Ray, et al.
Publicado: (2016)

A Novel Human Mutation in the SLC9A1 Gene Results in Abolition of Na(+)/H(+) Exchanger Activity
por: Li, Xiuju, et al.
Publicado: (2015)

Rainbow Trout (Oncorhynchus mykiss) Na(+)/H(+) Exchangers tNhe3a and tNhe3b Display Unique Inhibitory Profiles Dissimilar from Mammalian NHE Isoforms
por: Blair, Salvatore, et al.
Publicado: (2021)

Stop Codon Polymorphisms in the Human SLC9A1 Gene Disrupt or Compromise Na(+)/H(+) Exchanger Function
por: Li, Xiuju, et al.
Publicado: (2016)

Na(+)/H(+) exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells
por: Amith, Schammim Ray, et al.
Publicado: (2016)

Crosstalk between Sodium–Glucose Cotransporter Inhibitors and Sodium–Hydrogen Exchanger 1 and 3 in Cardiometabolic Diseases
por: Al-Shamasi, Al-Anood, et al.
Publicado: (2021)

The Na(+) /H(+) exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells
por: Amith, Schammim Ray, et al.
Publicado: (2014)

Amino Acids 785, 787 of the Na(+)/H(+) Exchanger Cytoplasmic Tail Modulate Protein Activity and Tail Conformation
por: Li, Xiuju, et al.
Publicado: (2021)

Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway
por: Achkar, Iman W., et al.
Publicado: (2018)

Cardiomyocyte Na(+)/H(+) Exchanger-1 Activity Is Reduced in Hypoxia
por: Kandilci, Hilmi Burak, et al.
Publicado: (2021)

Functional roles of Na+/H+ exchanger isoforms in saliva secretion.
por: Park, K, et al.
Publicado: (2000)

The effect of inhibition of the Na(+)/H(+) exchanger on the development of hypertrophy in hypertrophic cardiomyopathy
por: Brouwer, Wessel P, et al.
Publicado: (2011)

p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer
por: Poomakkoth, Noufira, et al.
Publicado: (2016)

Empagliflozin inhibits Na(+)/H(+) exchanger activity in human atrial cardiomyocytes
por: Trum, Maximilian, et al.
Publicado: (2020)

Stimulation of Na(+)/H(+) Exchanger Isoform 1 Promotes Microglial Migration
por: Shi, Yejie, et al.
Publicado: (2013)

Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1
por: Richards, Mark A, et al.
Publicado: (2019)

Osteopontin Expression in Cardiomyocytes Is Increased in Pediatric Patients With Sepsis or Pneumonia
por: Irion, Camila Iansen, et al.
Publicado: (2018)

Gene Expression Patterns of Osteopontin Isoforms and Integrins in Malignant Melanoma
por: Jámbor, Krisztina, et al.
Publicado: (2022)

Two different isoforms of osteopontin modulate myelination and axonal integrity
por: Nilsson, Gisela, et al.
Publicado: (2023)

Calpain-3-mediated regulation of the Na(+)-Ca(2+) exchanger isoform 3
por: Michel, Lauriane Y. M., et al.
Publicado: (2015)

Functional Differences in Ionic Regulation between Alternatively Spliced Isoforms of the Na(+)-Ca(2+) Exchanger from Drosophila melanogaster
por: Omelchenko, Alexander, et al.
Publicado: (1998)

Insulin-Induced Cardiomyocytes Hypertrophy That Is Prevented by Taurine via β-alanine-Sensitive Na(+)-Taurine Symporter
por: Jazzar, Ashley, et al.
Publicado: (2021)

Resistance to cardiomyocyte hypertrophy in ae3( −/− ) mice, deficient in the AE3 Cl(−)/HCO(3)(−) exchanger
por: Sowah, Daniel, et al.
Publicado: (2014)

The mitochondrial Na(+)-Ca(2+) exchanger, NCLX, regulates automaticity of HL-1 cardiomyocytes
por: Takeuchi, Ayako, et al.
Publicado: (2013)

Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential
por: Saadaoui, Imen, et al.
Publicado: (2020)

Na(+)-induced Ca(2+) influx through reverse mode of Na(+)-Ca(2+) exchanger in mouse ventricular cardiomyocyte
por: Yan, Zhen-Yu, et al.
Publicado: (2015)

Transmembrane Segment XI of the Na(+)/H(+) Antiporter of S. pombe is a Critical Part of the Ion Translocation Pore
por: Dutta, Debajyoti, et al.
Publicado: (2017)

Aberrant dynamin 2-dependent Na(+)/H(+) exchanger-1 trafficking contributes to cardiomyocyte apoptosis
por: Li, Jun, et al.
Publicado: (2013)

Functional Analysis of Conserved Transmembrane Charged Residues and a Yeast Specific Extracellular Loop of the Plasma Membrane Na(+)/H(+) Antiporter of Schizosaccharomyces pombe
por: Dutta, Debajyoti, et al.
Publicado: (2019)

Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na(+)/H(+) exchanger, lowering of cytosolic Na(+) and vasodilation
por: Uthman, Laween, et al.
Publicado: (2017)

Increased sarcolemmal Na(+)/H(+) exchange activity in hypertrophied myocytes from dogs with chronic atrioventricular block
por: van Borren, Marcel M. G. J., et al.
Publicado: (2013)

Na(+)/H(+) Exchanger 1, a Potential Therapeutic Drug Target for Cardiac Hypertrophy and Heart Failure
por: Xia, Huiting, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2rjc5mr3886bk1ghgvhqhksmac