Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity

The NADPH oxidase of neutrophils, essential for innate immunity, passes electrons across the phagocytic membrane to form superoxide in the phagocytic vacuole. Activity of the oxidase requires that charge movements across the vacuolar membrane are balanced. Using the pH indicator SNARF, we measured c...

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Detalles Bibliográficos
Autores principales: Levine, Adam P., Duchen, Michael R., de Villiers, Simon, Rich, Peter R., Segal, Anthony W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401748/
https://www.ncbi.nlm.nih.gov/pubmed/25885273
http://dx.doi.org/10.1371/journal.pone.0125906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401748/
https://www.ncbi.nlm.nih.gov/pubmed/25885273
http://dx.doi.org/10.1371/journal.pone.0125906

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